IL-6, CXCL10, CXCL9, CCL2, IL1-Ra, IL-10, G-CSF and TNF-α were the cytokines with the highest contribution to dimension 2 in the PCA (Figure 2B) and were significantly increased in acute COVID-19 patients in comparison to HC (Figure S2). The gene discussed is CSF3; the disease is COVID-19.