NLRP3 and chronic kidney disease: Notably, compared with the CKD mice, the NLRP3 KO CKD mice had a significantly shorter latency in reaching the hidden platform during the training period (Figure 9A) and probe trials (Figure 9C), a longer duration time at the target quadrant (Figure 9D), higher frequency entering the target quadrant (Figure 9E), and shorter latency in reaching the platform position (Figure 9F).