SPARCL1 and metabolic dysfunction-associated steatohepatitis: In addition, there was upregulation in the expression of MMP14 mRNA, ITGB1 mRNA, miR-6881-5p miRNA and lncRNA lnc-SPARCL1-1:2 by 3-fold, 1-fold, 1.6-fold and 1.8-fold, respectively, in NAFLD cases compared to healthy controls, by 5-fold, 5-fold, 3-fold and 9-fold, respectively, in simple steatosis cases compared to NAFLD cases, and by 2-fold, 1.7-fold, 11-fold and 21-fold, respectively, in NASH cases compared to simple steatosis cases (Table S1, Figure 4A–D).