CNR1 and metabolic syndrome: Indeed, some eCBome mediators, such as OEA and other non-CB1-activating NAEs, can be considered as biomarkers of metabolic health since their endogenous concentrations in blood or tissues correlate with, among others, increased lipolysis and insulin sensitivity and reduced body fat, dyslipidemia and systemic inflammation, with or without body-weight-reducing interventions [65,66,67], as well as with the dietary intake of the corresponding fatty acids [68].