The role of IL-8 (CXCL8) on glioblastoma multiform CSCs has also been reported by Infanger et al. (2013) through a three-dimensional system of endothelial cells and CSCs that showed enhanced secretion of IL-8 by the endothelial cells that promoted the CSCs’ migration, growth, and stemness properties [98]. This evidence concerns the gene CXCL8 and glioblastoma.