seventeen studies identified a significantly ↑ systemic inflammatory response after OSR with ↑ cytokine levels, especially of IL-6 and IL-8; some studies yielded contradictory results or showed no differences between OSR and EVA regarding levels of IL-1β, IL-10, and TNF-α [145]post-interventional normalization of the inflammatory state, preoperative serum levels (50–100 pg/mL) of IL-1α and IL-8 significantly dropped six months post-EVAR [146]preoperative IL-1α serum concentrations correlated with AAA size, serum IL-1α levels and neutrophil recruitment decrease post-EVAR [146]. The gene discussed is IL1A; the disease is triple-A syndrome.