Moreover, using the Western pattern diet-induced NAFLD, the levels of reactive species, including ROS and RNS, are significantly increased in the livers of heterozygous mice carrying hepatocyte-specific knockout of Cisd2 (Cisd2hKO+/–) while overexpression of Cisd2 alleviates the Western pattern diet-induced oxidative stress in Cisd2TG mice [18]. The gene discussed is CISD2; the disease is metabolic dysfunction-associated steatotic liver disease.