KLK3 and posterior cortical atrophy: Concordant with these findings, in a recent study that prospectively evaluated six candidate biomarkers for detection of pelvic lymph node (LN) metastases (pN1) and prediction of BRFS in treated patients, while KLK2 and KLK3 outperformed the other predictive variables, and correctly classified all pN1 cases as molecular node-positive, KLK3 exhibited the highest concordance (96%) with histopathology for detection of LN metastases in the patients with PCa [22,23], and KLK3 protein expression was significantly enhanced in recurrent PCa tissues compared to the ‘normal’ tissues [24].