CD5L and cancer: Furthermore, corollary to published reports indicating that by binding to human regulator of complement activation (RCA), and blocking the RCA activity, AIM/CD5L facilitates the immune recognition of cancer cells [21], we also demonstrated that not only does the functional association between PSA and AIM modulate metastasis, but that it mirrors the immunogenicity, and differentially modulate Treg, T-cell and macrophage activities in patients with PCa (Figure 5 and Figure 6).