Cognizant of the usually long course of PCa, and the increasing prevalence of metastatic disease, as well as the high risk of local recurrence or progression to metastatic disease, and eventually death, despite initial definitive local treatment [1,2,3], it is of translational relevance that we found that a high PSA/AIM expression ratio is associated with enhanced metastability, and disease recurrence in patients with PCa, whereas, a high AIM/PSA ratio is associated with strong castration-induced regression (Figure 3 and Figure 4). Here, KLK3 is linked to posterior cortical atrophy.