KLK3 and cancer: Using the cancer dependency map platform (https://depmap.org/portal/interactive/, accessed on 30 January 2021), we observed that CRISPR-induced suppression of aim/cd5l gene effect, elicited upregulated PSA transcript expression in LNCaP clone FGC, 22RV1, VCAP, P4E6, and BPH1 PCa cell lines (Pearson r = −0.20, Slope = −7.28, linregress p = 0.75) (Figure 1F, right).