TMPRSS2 and metastatic malignant neoplasm: Next, cognizant of the culpability of androgen receptor (AR) signaling or TMPRSS2:ERG gene fusion in PCa metastasis and disease progression, we re-analyzed Robinson et al.’s data on whole-exome and transcriptome sequencing of ~500 metastatic cancer samples (MET500) [15], and showed that AIM/CD5L mRNA expression was 1.51-fold (p = 0.28) upregulated in the PCa samples without AR-amplification, compared to the AR-amplified samples from the MET500 metastatic PRAD cohort (Figure 4H, upper left).