Our results showed that relative to downregulated AIM/CD5L expression, PSA/KLK3 is co-upregulated with regulatory T-cell (Treg) markers IL7, and VEGFA in localized PCa, or with VEGFA, and ITGAE in castration-resistant bone metastatic PCa (Figure 6A). This evidence concerns the gene VEGFA and posterior cortical atrophy.