Our findings are in line with the recent study by Francischetti et al., which illustrates a normal expression of thrombomodulin in the alveolar capillaries of control cases and the loss of the protein in COVID-19 patients [53]; as suggested by the authors, an upregulation of pulmonary TF with the loss of thrombomodulin emerge as a potential link to immunothrombosis in COVID-19. This evidence concerns the gene THBD and COVID-19.