The FH phenotype can be caused by pathogenic variants in the three FH-associated genes (APOB, LDLR, and PCSK9) or by pathogenic variants in several phenocopies or alternative molecular etiologies (ABCG5/8, APOE, LDLRAP1, and LIPA), or it can even be due to a polygenic cause [3,4,5,6]. This evidence concerns the gene PCSK9 and familial hyperaldosteronism.