Suppression of BRK1 as a result of miR-181c overexpression has been known to reduce protein expression of WAVE2 complex (WAVE2, ABI1, SRA1 and HEM1) in HeLa [80], osteosarcoma U2OS cell lines, Jurkat and primary T cells [118,119,120]. The gene discussed is WASF2; the disease is osteosarcoma.