Thus, although the ROC analysis of a regression model showed a good discriminative power to discriminate between controls and patients with AUD, a second regression model with LPA, ATX, and AUD-related variables (i.e., abstinence, problematic alcohol use, and AUD severity) showed an excellent discriminatory power to distinguish patients with alcoholic liver disease from patients without alcoholic liver disease. The gene discussed is ENPP2; the disease is alcoholic liver diseases.