Because the presence of comorbid liver disease in patients with AUD was associated with differences in plasma concentrations of ATX, we examined the correlation between the ATX–LPA axis and relevant alcohol-related variables (i.e., the last period of alcohol abstinence, the problematic alcohol use, and the severity of AUD) in the subgroups of patients with AUD based on the diagnosis of liver disease. This evidence concerns the gene LPA and liver disorder.