In this cross-sectional study, plasma concentrations of total LPA and ATX were measured in healthy control subjects and abstinent patients with AUD, who displayed an elevated prevalence of alcoholic liver diseases (35%: fatty liver/steatosis (56.5%), alcoholic steatohepatitis (34.8%), and cirrhosis (8.7%)) through a non-randomized strategy for the recruitment process. This evidence concerns the gene ENPP2 and alcoholic fatty liver disease.