Decreased THRSP serum levels is reported in patients with metabolic syndrome (increased BMI, HbA1c, triglycerides, alanine-transaminase, and lower HDL-C) compared to healthy individuals, supporting a differential regulation of THRSP when (lipid) metabolism is altered; however, hepatic histopathological status was not recorded, preventing cross-referencing to NASH [48]. This evidence concerns the gene GPT and metabolic dysfunction-associated steatohepatitis.