SMO and leiomyosarcoma: Additionally, the blocking of SMO (LDE225) and GLI (GANT61) function by Hh inhibitors effectively reduced proliferation, migration, and invasion of leiomyosarcoma cell lines [83], and together with the previous results, suggested that PTCH1 downregulation can promote carcinogenesis of leiomyosarcoma cells through SMO derepression and subsequent GLI activation.