GLI1 and esophageal adenocarcinoma: Interestingly, a study by Wang et al. reported that in esophageal adenocarcinoma cell lines, TNFα stimulation and ectopic SK61 expression regulate GLI1 activity by phosphorylation of its Ser84 residue, thereby dissociating GLI1 from SUFU and allowing GLI1 translocation into the nucleus [111].