Interestingly, ectopic GLI1 expression in KRAS-expressing mice enhanced IKBKE expression and nuclear RelA staining, and the knockdown of IKBKE expression in pancreatic cancer cell lines impaired their ability to grow in soft agar and induced apoptosis by caspase 3 cleavage [95]. The gene discussed is CASP3; the disease is familial pancreatic carcinoma.