Additionally, the blocking of SMO (LDE225) and GLI (GANT61) function by Hh inhibitors effectively reduced proliferation, migration, and invasion of leiomyosarcoma cell lines [83], and together with the previous results, suggested that PTCH1 downregulation can promote carcinogenesis of leiomyosarcoma cells through SMO derepression and subsequent GLI activation. This evidence concerns the gene GLI1 and leiomyosarcoma.