PTCH1 and skin basal cell carcinoma: In the adult IFE cells, SMOM2 expression drove the formation of invasive-type BCC in transgenic mice, which was associated with enhanced expression of Hh pathway genes (GLI1/2, PTCH1/2, and HHIP) and embryonic hair follicle progenitor markers (P-cadherin, LHX2, and CUX1).