As Gal-1 is restricted to the stromal compartment as assessed in pancreatic tumor specimens, Gal-1 could potentially induce GLI1 expression in tumor epithelium cells via paracrine induction, recapitulating the importance of stromal-derived Gal-1 in inducing GLI1 expression in the surrounding tumor [122]. Here, GLI1 is linked to pancreatic neoplasm.