PTK2 and neoplasm: Moreover, in the phase-I EDALINE study, tumor specimens of high responders to docetaxel were cotreated with sonidegib and characterized by elevated Hh ligand expression, GLI1 expression, ECM remodeling, FAK signaling, phosphor-FGFR (receptor of FGF-5), and ALDH1 (CSC marker)-positive cells [58].