To further corroborate the importance of SMO in colorectal cancer tumorigenesis, Magistri et al. revealed that treating HCT 116, SW480, and SW620 colon cancer cell lines with SMO inhibitors or siRNA reduced cell proliferation via upregulation of p21 and downregulation of CCND1 and suppressed migration and three-dimensional invasion via downregulation of SNAI1 and induction of epithelial markers Cytokeratin-18 and E-cadherin. This evidence concerns the gene SMO and malignant colon neoplasm.