Mutations in PTCH1 and SMO, although to a lesser degree than BCC, have also been detected in other cancers such as medulloblastoma [54], mesothelioma [134], cervical cancer [61], breast cancer [57], odontogenic keratocystic tumors [55], acute lymphoblastic leukemia [56], and hepatocellular carcinoma (HCC) [68,135]. Here, SMO is linked to acute lymphoblastic leukemia.