GLI1 expression has also been reported to be regulated by PI3K/AKT/mTOR signaling in several other cancers to promote tumorigenesis, including esophageal adenocarcinoma [106], melanoma [113], osteosarcoma [107], pancreatic cancer, ovarian cancer [108], and renal cancer [109]. Here, GLI1 is linked to familial pancreatic carcinoma.