However, Liu et al., finding that two different breast cancer cell lines (BT-483 and MDA-MB-231) required different concentrations of curcumin to achieve similar levels of cell proliferation [29], proposed that curcumin’s activity depended on down-regulating the NF-kB inducing genes, and different cell lines showed different dependences on this pathway. The gene discussed is NFKB1; the disease is breast cancer.