AKT2 and lung cancer: A team has systematically investigated a series of genes relevant to RP in lung cancer patients, and found that the SNP rs4665162 of integrin beta6 subunit (ITGB6) gene, rs1144393 in matrix metalloproteinase-1 (MMP-1) gene, and three SNPs in the phosphatidylinositol 3-kinase (PI3K)/AKT pathway (PI3CA: rs9838117, AKT2: rs33933140 and rs11880261) were associated with higher RP risk [105,107,108].