Similarly, several hypotheses have been formulated regarding the link between genome mutations, such as GCK, HLA antigens, INSR, IGF2, HNF4A, INS-VNTR, HNF4a, CAPN10, MBL2, KCNJ11, ABCC8, ND1, TCF7L2, ADIPOQ, and PAI-1, and the development of GDM [48,49,50]. The gene discussed is TCF7L2; the disease is gestational diabetes.