In our previous study, approximately 90% of hypouricemia patients showed two variants in SLC22A12, p.W258* and p.Arg90His, in two independent cohorts, the Korean Genome and Epidemiology Study (KoGES, n = 179,318) and the Korean Cancer Prevention Study (KCPS-II, n = 156,701) [14]. The gene discussed is SLC22A12; the disease is cancer.