Based on their observations of considerably decreased plasma levels of active TGF-β1 in resveratrol-fed mice and increased levels of total reversible oxidations of proteins in Fbn1mgR/mgR mice compared to wild-type mice, the authors suggested that resveratrol may diminish the incidence and mortality of aortic aneurysm via reduction of oxidative post-translational modifications of SirT-1 in VSM cells and inhibition of excessive TGF-β1 in Fbn1mgR/mgR mice [121]. Here, TGFB1 is linked to aortic aneurysm.