Jiménez-Altayó et al. [69] provided confirmation of the involvement of NADPH oxidase-dependent ROS in the formation of an aneurysm in Marfan’s syndrome since they demonstrated decreased aneurysm size and ECM breakdown in Fbn1C1039G/+/-Nox4−/− mice [69]. The gene discussed is FMO5; the disease is aneurysm.