Lima et al. confirmed that both NLRP3 and caspase 1 were upregulated in lesional epidermis of HS, demonstrating by Western blot analysis that caspase-1 p10, the active form of caspase 1, resulted significantly increased in keratinocytes obtained from lesional skin as compared with perilesional skin [117]. The gene discussed is NLRP3; the disease is histiocytic sarcoma.