LGALS3 and pancreatic ductal adenocarcinoma: Other polysaccharide derivatives include “RN1” and “HH1-1.” Zhang and coworkers demonstrated that RN1 binds to Gal-3 and blocks Gal-3-mediated downstream signaling, which suppresses transcription factors, such as RUNX binding to the Gal-3 promoter in pancreatic ductal adenocarcinoma [105].