On this basis, we aimed at assessing social anxiety-like behaviour, the response to novelty and the sensitivity to natural positive stimuli, and coping strategies against inescapable stress, together with corticosterone secretion and hypothalamic and extrahypotalamic CRH expression, at different stages of the drinking paradigm: during binge days (BD), at withdrawal day 1 (WD1) and withdrawal day 10 (WD10). The gene discussed is CRH; the disease is Anxiety.