In detail, CRH levels significantly increased at WD10 with respect to CTRL (t = 5.47, df = 24, p < 0.0001), BD (t = 7.12, df = 24, p < 0.0001) and WD1 (t = 4.39, df = 24, p< 0.0001) (Figure 2D,E). Here, CRH is linked to Behcet disease.