Overall, the current evidence evokes a new frame of reference, where, during withdrawal from binge-like alcohol exposure, an anxiety-prone phenotype, characterized by an upregulated response to stress plus reduced sensitivity of the reward system, is associated with dysfunctional synaptic remodeling, probably via the interplay between the augmented CRH expression and the limited availability of accumbal DA [127]. This evidence concerns the gene CRH and Anxiety.