As to the effect of liver regeneration on the malignant hepatic tumor following major surgery, liver regeneration might be driven by the overexpression of EGF, HGF, and IGF-1, which could activate hidden micrometastases and facilitate tumor growth; this results in liver tumor recurrence, and also stimulates intrahepatic tumor propagation due to abnormalities in the cellular signaling pathways [21]. This evidence concerns the gene HGF and neoplasm.