There is a notable relationship between I/R, HCC, and the activation of VEGF (involved in both regeneration and tumorigenesis, as mentioned) with EGF, IGF-1, and HGF; this is of great importance, not only because I/R is intrinsic to liver resection but because this process is associated with increased inflammation in the remaining liver tissue. Here, EGF is linked to hepatocellular carcinoma.