OPCML and prostate cancer: For example, an miRNA-target association type between mir-224 and Gastric Neoplasms predicted by our method mDLinker was confirmed by Fang et al. [36], and mir-224-5p negatively regulates OPCML in gastric cancer tissues; the abnormal expression of miR-148a in prostate cancer predicted by MDLinker is consistent with the findings by Fujita et al. [37] that the expression level of miR-148a in PC3 and DU145 hormone-resistant prostate cancer cells is lower than that in PrEC normal prostate epithelial cells.