In a contradictory way, other researchers confirm that HFD with a high content of SAFA increases the expression and activity of DPP-IV in the aorta and atrium, playing a role in the development of aortic stiffness, vascular oxidative stress, endothelial dysfunction, and vascular remodeling by promoting increased deposition of collagen fibers [84,85,86]. This evidence concerns the gene DPP4 and endothelial dysfunction.