TNF and renal cell carcinoma: GSEA revealed pathways cooperating together in RCC tumorigenesis: enrichment of EMT, modifications of immune system signaling through various cytokines, HYPOXIA, which further affects positively ANGIOGENESIS and GLYCOLYSIS and negatively OXIDATIVE PHOSPHORYLATION pathways, TNFα signaling causing enhancement of NF-kB activity and APOPTOSIS and decreasing of ADIPOGENESIS, and concurrent negative enrichment of FATTY ACID and XENOBIOTIC METABOLISMS pathways in the HALLMARK database, all with q < 0.05.