CD4 and neoplasm: On the other hand, GPSM3 showed significant negative correlation with tumor purity (r = −0.48, p = 2 × 10−58), and moderate to strong positive association with six types of immune infiltrate cells (dendritic cell, r = 0.65; CD4+ T cell, 0.64; neutrophil, 0.56; B cell, 0.44; CD8+ T cell, 0.36; and macrophage, 0.29; all p values < 10−20).