PKM and diabetes mellitus: At first view, our findings seem to be at odds with recent proteomic studies in individuals with very long diabetes duration (≥50 years), which indicated that glycolytic enzymes, particularly PKM2, were elevated in glomeruli and plasma of patients without diabetic nephropathy compared with patients with this complication, thus suggesting a protective role for PKM2 by increasing glucose flux through glycolysis [56,57].