DYRK1A and early-onset autosomal dominant Alzheimer disease: Furthermore, several synthetic meridianin analogs showed potent and selective inhibitory effects over glycogen synthase-3 (GSK-3) and dual-specificity tyrosine-phosphorylation regulated kinase 1A (DYRK-1A), which are known to be implicated in the progression of Alzheimer’s disease [2,32].