Furthermore, several synthetic meridianin analogs showed potent and selective inhibitory effects over glycogen synthase-3 (GSK-3) and dual-specificity tyrosine-phosphorylation regulated kinase 1A (DYRK-1A), which are known to be implicated in the progression of Alzheimer’s disease [2,32]. The gene discussed is DYRK1A; the disease is Alzheimer disease.