BACE1 and Cognitive impairment: Furthermore, the increased BACE1 and mRNA stabilizing antisense (BACE-1-AS) is silenced by NRF2 by linking with antioxidant response elements, whereas the NRF2 deficiency upregulates the BACE-1 and BACE-1-AS expression and Aβ generation thereby enhancing the cognitive impairment [207].