Similarly, the transcriptional regulation of Aβ is validated upon studying several genes including (I) the amyloidogenic genes such as ADAM10, BACE1, PS1, PS2, Nicastrin and APP, (II) AD risk genes APOE and TREM2, (III) learning and memory factors genes such as NMDAR and PKC zeta, (IV) kinases which contribute for p-tau including GSK3α, GSK3β and Cdk5 and (V) enzyme 1α-hydroxylase (1αOHase). The gene discussed is APOE; the disease is Alzheimer disease.