Expression of transcription genes (anti-oxidative and mitochondria-related proteins) in AβO treated BV2 (glial) and SH-SY5Y (neuronal) cells, transgenic mice (Tg-AD), and human AD brain revealed enhanced expression of Sod2, Dnm1l, Bcl2 genes and reduction of Gpx4, Sirt1, Sirt3, mt-Nd1, Sdha and Mfn2 genes. The gene discussed is GPX4; the disease is Alzheimer disease.