Pathological trademarks of AD involve classical positive lesion comprising of amyloid plaques composed of Aβ peptides in the synaptic terminal of brain parenchyma and in the cerebral blood vessels leading to congophilic angiopathy/cerebral amyloid angiopathy (CAA); NFTs composed of paired helical filaments with hyperphosphorylated tau in the axonal region, neuropil threads, and dystrophic neurites accompanied by microgliosis and astrogliosis [11]. Here, MAPT is linked to Alzheimer disease.