From the panel of selected genes in this study, we presented that gene variants such as: CAT, rs1001179-nonCC, ABCB1 rs2032582–CC, GPX1 rs1050450-CC, CRTC3 rs12915189-nonGG significantly enhanced already greater CRC occurrence among women with ≤0.67 μg/L blood-As concentration, although none of these genotypes presented a significant effect on CRC occurrence on their own when blood-As levels were not considered. This evidence concerns the gene ABCB1 and colorectal carcinoma.