CAT rs1001179-nonCC, ABCB1 rs2032582–CC, GPX1 rs1050450-CC, CRTC3 rs12915189-nonGG polymorphisms enhance the already existing, increased probability of female CRC occurrence associated with low blood-As levels (0.27–0.67 μg/L). Here, CRTC3 is linked to colorectal carcinoma.