Other studies have shown that curcumin can inhibit several molecules involved in the TGF-β-pathway-induced fibrosis, including NF-Kb and the p38 MAP kinase [130] and increase the expression of a variety of tumor-suppressor proteins, such as p21 and p53, thus leading to inhibition of tumor invasion and cell migration [131]. The gene discussed is TP53; the disease is neoplasm.