In addition to these properties, curcumin has demonstrated the ability to suppress AR gene transcription in prostate cancer cells in vitro downregulating AR expression in the lymph node carcinoma of the prostate (LNCaP) cell line by inhibition of the expression of steroidogenic acute regulatory proteins, such as HSD3B2 and CYP11A1 [67]. The gene discussed is AR; the disease is prostate cancer.