On prostate-CAFs, curcumin can increase the intracellular ROS levels and induce G2/M arrest [132], while in tongue squamous cell carcinoma, curcumin has been found to inhibit the secretion of pro-carcinogenic cytokines, including stromal cell-derived factor-1 (SDF-1) and matrix metalloproteinases 2 (MMP2) [133]. Here, CXCL12 is linked to tongue squamous cell carcinoma.