In rBM-MSCs, the levels of the CatD, and CatS, were significantly decreased (>100%) at the ALS-PreS and the End-stage of the disease with respect to WT counterpart (Figure 6B), whereas, CatB decreased with the progression of the disease (ALS1-EndS >100% to WT) (Figure 6B; Figure S4C, Supplementary File). The gene discussed is PIMREG; the disease is amyotrophic lateral sclerosis.