Finally, we found a reduced expression of CatB in the ALS1-EndS brain and heart (52% and 44%, respectively) with respect to WT counterparts, which were comparable with the levels of ALS-PreS, instead of CatB levels that increased with the progression of the disease (ALS1-EndS 95% to WT) in muscle tissue (Figure 5; Figure S4A in Supplementary File). The gene discussed is TYRP1; the disease is amyotrophic lateral sclerosis.