For instance, mutations of the C9orf72 (Chromosome 9 open reading frame 72) gene have been shown to affect the activity of Rab protein, with the induction of endo-lysosomal pathway dysfunction, altered autophagy, and accumulation of protein aggregates in ALS-FTD1 [62]. This evidence concerns the gene C9orf72 and amyotrophic lateral sclerosis.