SOD1 and amyotrophic lateral sclerosis: The ratG93A developed the ALS1 disease in 6 months, and, during this period, the level of SOD1* increases drastically and allows to distinguish between two distinct stages of the disease: Pre-symptomatic stage (absence of ALS symptoms; ALS1-PreS), and Terminal stage (exhibition of human typical ALS terminal phenotype; ALS1-EndS) [23].