The target identification analysis revealed enrichment of miR-30c-5p validated targets related to different cancer pathways such as p53 and Wnt signaling pathways, etc. Finally, 31 gene targets, negatively correlated to miR-30c-5p tissue expression (TCGA data), were shown to possess clinical significance as their high expression determined shorter overall survival (OS), when considered as a group. This evidence concerns the gene TP53 and cancer.