The proapoptotic role of STIM1/ORAI1-based SOCE is reversed in non-small cell lung cancer (A549), ovary carcinoma (A2780), pancreatic adenocarcinoma (HC67, Panc1, Capan1, ASPC1, and MiaPaca2), multiple myeloma (immortalized human cell lines and patient-derived tumor cells), and melanoma (B16BL6-8) with the general accompaniment of elevated Akt pathway activity [277,281,282,283,284,285]. The gene discussed is ORAI1; the disease is neoplasm.