A similar role for STIM1/ORAI mediated SOCE has been observed in cervical cancer, hepatocellular carcinoma, renal cell carcinoma, nasopharyngeal cancer, and glioblastoma where this Ca2+ influx regulates focal adhesion turnover, cytoskeletal reorganization, and actomyosin-based mechanotransduction [291,292]. Here, STIM1 is linked to hepatocellular carcinoma.