Ano1, or TMEM16A, a Ca2+-activated chloride channel (CaCC) at the ER-PM junction, is highly upregulated in several cancer types—gastrointestinal tumors, head and neck squamous carcinoma, glioblastoma, pancreatic, breast, and colorectal cancer— as a pro-proliferative and pro-migratory signaling molecule [312,313,314,315,316,317]. The gene discussed is ANO1; the disease is glioblastoma.