Variants in NAD(P)H oxidase subunits have been proposed to result in both acute and chronic forms of cardiotoxicity via ROS formation; [23,24,25] Cascales et al. examined cardiac histology among recently deceased patients treated with anthracyclines and discovered a five-fold increased odds (95% CI: 1.59–16.43) of cardiac interstitial fibrosis in the presence of the rs1883112 SNP in the p40phox subunit of NAD(P)H oxidase [26]. The gene discussed is FMO5; the disease is Interstitial cardiac fibrosis.