NR4A2 and obesity due to melanocortin 4 receptor deficiency: Specifically, current evidence shows that the developmental programming of chronic conditions, such as diabetes, cardiovascular disease, obesity, and depression, has a transgenerational effect [11,62] through the excessive expression of the glucocorticoid-responsive transcription factor called nuclear-receptor related 1 protein (NURR1) with environmental stress interactions during early life [63].