Moreover, as SARS-CoV-2 depletes angiotensin-converting enzyme 2 (ACE-2), causing significant renin-angiotensin system disequilibrium, it is thought that following infection, a prothrombotic state with impaired large vessel and microvascular blood flow can occur and lead to an increased risk of thrombotic and hemorrhagic stroke [54]. This evidence concerns the gene ACE2 and hemorrhagic stroke.