BRAF V600E-mutated pLGGs with the presence of the CDKN2A (Cyclin-Dependent Kinase Inhibitor 2A) deletion, more commonly described in pleomorphic xanthoastrocytoma, have a highly increased risk to transform to HGG in one or two decades [4,23]. Here, CDKN2A is linked to pleomorphic xanthoastrocytoma.