ESR1 and Glucose intolerance: Liver-specific disruption of ERα signaling in males leads to altered expression of genes involved in GNG (e.g., Pck1, G6pc) and lipid metabolism (e.g., Fasn, Acaca) and to impaired FOXO1 phosphorylation, resulting in an insulin-resistant phenotype characterized by enhanced HGP, glucose intolerance, increased hepatic lipogenesis, lipid deposition and inflammation in the liver [80,126,138,395,396].