C4B and Insulin resistance: In OVX female rodents fed with a high-fat high-fructose (HFHF) diet, estrogen administration combined with exercise prevents the development of insulin resistance, limits hepatic fat accumulation by increasing FAO and suppressing DNL in the liver and ameliorates the circulating lipid profile by reducing lower serum TG levels, decreasing LDL-CH and increasing HDL/CH ratio [388].