Although effective in reducing hepatic steatosis [81,143,144,351,352], the administration of constant amounts of estrogens as well as of SERMs (selective estrogen receptor modulators) partially restores a proper regulation of hepatic metabolism, likely as a consequence of the inability to reproduce the physiological, cyclic activation of hepatic ERα associated with estrous cycle progression in females [12,81,106,352]. This evidence concerns the gene ESR1 and Hepatic steatosis.