PPARA and fatty liver disease: However, the specific contribution of hepatic AR differs between the two sexes; in fact, only LARKO male but not female mice develop hepatic steatosis and insulin resistance as a result of the over-regulation of genes involved in DNL (Srebp-1c, Acaca, and Pparγ) and downregulation of genes involved in FAO (e.g., Pparα) [173,177].