IDE and diabetic kidney disease: Not only is canonical autophagy associated with the inflammatory status, but SA may be implicated in: (1) some inflammatory mediators, such as IL-1beta, released through this pathway [41]; (2) some inflammation-related enzymes in DKD, such as insulin-degrading enzyme (IDE), which are also released following an autophagy-linked secretion process; and (3) a close interplay between secretory and canonical autophagy [16].