AGER and breast cancer: Further studies showed that soluble RAGE expressing the extracellular part of RAGE and neutralizing antibodies to RAGE interfered with the anti-tumor function of neutrophils toward several tumor cell lines (e.g., AT3 breast cancer, E0771 breast cancer, LLC lung carcinoma and B16-F10 melanoma), suggesting a role for RAGE in the interaction between the tumor cells and neutrophils [238].