TNF and neoplasm: The anti-tumor “N1” phenotype exhibited increased tumor cytotoxicity, elevated expression of CXCL13, CCL3, CCL6, CXCL10, TNFα and ICAM-1 and low ARG1 content, while the pro-tumor “N2” neutrophils expressed high levels of ARG1, MMP9, VEGF and several cytokines, including CCL2, CCL5, CCL17 and CXCL4 [75,193,194].