The activated neutrophils kill the tumor cells by a combined effect of reactive oxygen and nitrogen species, such as hydrogen peroxide (H2O2), superoxide anion (O2−·), hypochlorous acid (HOCl) and nitric oxide radical (NO·), together with FasL and TRAIL [53,60,75,118,167,168,202,219,221,222,223,224,225] (Figure 3). This evidence concerns the gene TNFSF10 and neoplasm.