AGER and breast cancer: RAGE KO breast cancer cells showed impaired metastatic seeding capacities [238], and, in a metastatic seeding model where GFP-expressing AT3 breast cancer cells were injected intravenously into mice that have been transplanted with bone marrow (BMT) from either wild-type or CathG KO mice [238], the AT3 cells formed metastases in the lung of wild-type BMT mice, while no metastatic seeding of AT3 was observed in the CathG KO BMT mice (Figure 6D).