AKT1 and cancer: In addition, oncogenic growth-signaling cascades, including phosphoinositide 3-kinase (PI3K)-protein kinase B (AKT), mitogen-activated protein kinase (MAPK), CD44, c-Src, and c-Met, which are enriched in lipid rafts and related to both cancer development and progression, are tightly controlled by intracellular cholesterol levels [2,5].