This is based on the previous observations that downregulation of elevated PI3K-AKT-mTOR signaling, via miR-101 [58], lncRNA GAS5 and miR-23a [59] or miR-29a [60], resulted in reducing the extent of chronic liver damage by decreasing hepatic stellate cells activation and liver fibrosis. The gene discussed is AKT1; the disease is Hepatic fibrosis.