Interestingly, tumor cells with large amounts of cytoplasmic E-cadherin, β-actin and syndecan-1 frequently switch from a polygonal cell shape to a highly elongated shape, suggestive of increased migratory capacity, and this elongated morphology can also be seen against the surrounding stroma by WGA staining (arrows in Figure 5). The gene discussed is SDC1; the disease is neoplasm.