An unexpected finding in the present study was that knock-out of the P2X7R was associated with higher release of cytokines post-status epilepticus, including both pro- and anti-inflammatory cytokines (e.g., IL-10, IL-12p70, IL-27/30, IL-4, KC/GRO MIP-1α, MIP-2, TNF-α). Here, TNF is linked to status epilepticus.