However, numerous PD cases are heritable in an autosomal dominant manner including α-syn (SNCA), leucine-rich repeat kinase 2 (LRRK2), ubiquitin carboxyl-terminal hydrolase L1 (UCH-L1), and VPS35, which all-cause late-onset PD resembling sporadic PD. This evidence concerns the gene VPS35 and Parkinson disease.