Although it is not clear whether these mechanisms are causally involved in a similar way in human TAA or AD, there is gathering evidence that VSMC dysfunction and dysfunctional mechanosensing of the aortic wall are crucial features in the pathophysiology of both aortic aneurysms and dissections [68], and these findings emphasize the potential importance on NLRP3 in this context. Here, NLRP3 is linked to aortic aneurysm.