PTX3 and hereditary clear cell renal cell carcinoma: PTX3 binds C1q and activates or regulates the classic pathway, by interacting with M-ficolins and MBL can modulate the lectin pathway; moreover, at a soluble level, PTX3 interacts with Factor H. In prostate cancer and renal cell carcinoma, increased tissue and serum expression of PTX3 has been assessed and correlated with poor prognosis.