By using SH-SY5Y neuroblastoma cells, An et al. demonstrated that miR-124 is a potent negative regulator of β-site amyloid precursor protein-cleaving enzyme (BACE1) and that it may be involved in Alzheimer’s disease (AD) pathology, considering its reduced expression in AD sporadic patients [8]. The gene discussed is BACE1; the disease is Alzheimer disease.